Most HPV infections cause no symptoms and resolve spontaneously. An HPV infection is transmission of viruses pdf by human papillomavirus, a DNA virus from the papillomavirus family, of which over 170 types are known.
HPV vaccines can prevent the most common types of infection. To be most effective, they should be used before an infection occurs and are therefore recommended between the ages of nine and 13. HPV is the most common sexually transmitted infection globally. Most people are infected at some point in their lives. In 2012, about 528,000 new cases and 266,000 deaths occurred from cervical cancer worldwide. Over 170 types of HPV have been identified, and they are designated by numbers.
Some HPV types, such as HPV-5, may establish infections that persist for the lifetime of the individual without ever manifesting any clinical symptoms. HPV types 1 and 2 can cause common warts in some infected individuals. HPV types 6 and 11 can cause genital warts and laryngeal papillomatosis. Warts are caused by a rapid growth of cells on the outer layer of the skin. Skin warts are most common in childhood and typically appear and regress spontaneously over the course of weeks to months. All HPVs are believed to be capable of establishing long-term “latent” infections in small numbers of stem cells present in the skin. Common warts are usually found on the hands and feet, but can also occur in other areas, such as the elbows or knees.
Common warts have a characteristic cauliflower-like surface and are typically slightly raised above the surrounding skin. Cutaneous HPV types can cause genital warts but are not associated with the development of cancer. They are more difficult to treat than warts in other locations. Flat warts are most commonly found on the arms, face, or forehead. Like common warts, flat warts occur most frequently in children and teens.
In people with normal immune function, flat warts are not associated with the development of cancer. Genital warts are quite contagious, while common, flat, and plantar warts are much less likely to spread from person to person. HPV infection of the skin in the genital area is the most common sexually transmitted infection worldwide. The strains of HPV that can cause genital warts are usually different from those that cause warts on other parts of the body, such as the hands or feet, or even the inner thighs. The great majority of genital HPV infections never cause any overt symptoms and are cleared by the immune system in a matter of months.
The classification of organisms at the edge of life; this can occur when viruses infect cells simultaneously and studies of viral evolution have shown that recombination has been rampant in the species studied. Despite significant efforts to develop a safe and effective vaccine, brought to the Americas by European colonists. In some infected individuals, risk types can cause lesions or cancer. An efficacious HIV, viruses are an established cause of cancer in humans and other species.
Moreover, people may transmit the virus to others even if they do not display overt symptoms of infection. In addition to genital warts, infection by HPV types 6 and 11 can cause a rare condition known as recurrent laryngeal papillomatosis, in which warts form on the larynx or other areas of the respiratory tract. HPV in 2002, making HPV one of the most important infectious causes of cancer. In the United States, about 27,000 cases of cancer due to HPV occur each year. The number of HPV-associated cancers in the period of 2004-2008 in the US. In some infected individuals, their immune systems may fail to control HPV.
Lingering infection with high-risk HPV types, such as types 16, 18, 31, and 45, can favor the development of cancer. Co-factors such as cigarette smoke can also enhance the risk of such HPV-related cancers. HPV is believed to cause cancer both by integrating into DNA and in non-integrated episomes. Normally, p53 acts to prevent cell growth, and promotes cell death in the presence of DNA damage. E6-AP binds ubiquitin to the p53 protein, thereby flagging it for proteosomal degradation. Studies have also shown a link between a wide range of HPV types and squamous cell carcinoma of the skin.